Investigating anticancer potency of in vitro propagated endemic Thymus cilicicus Boiss. & Bal. extract on human lung, breast, and prostate cancer cell lines

Cancer is the leading cause of death in world, accounting for nearly 10 million deaths 2020 alone and surpassing all other categories by a large margin. Several different strategies have been are still being deployed to combat types cancers among common clinical approaches use synthetic natural compounds as anticancer agents within chemotherapy regimens. Thymus cilicicus Boiss. & Bal spice endemic Turkey, Northern Aegean Islands, Lebanon, Syria, while several species genus known exhibit clinically valuable properties, research on T. rather scarce, therefore, this study, wound healing properties vitro propagated ethanolic extracts were investigated murine fibroblast (NIH-3T3), its potency was human alveolar basal epithelial adenocarcinoma (A549), breast (MDA-MB-213), prostate cancer (DU-145) cell lines via colorimetric 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays. The property assessments didn’t lead any significant results, however, yielded selective promising A549 line. Furthermore, molecular docking analyses proteins 9 genes confirmed be upregulated both 3D 4D cultures against 48 found essential oils performed results acquiescent with previous findings scientific literature. This study provides evidence activity cells enhanced computational mechanism involved activity. serves precursor further vivo constituents potent their potential therapies.